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butabarbital will reduce the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. The efficacy of hormonal contraceptives may be minimized.butabarbital will reduce the extent or effect of carvedilol by influencing hepatic enzyme CYP2C9/